Statistical Effective Fault Attacks: The other Side of the Coin

The introduction of Statistical Ineffective Fault Attacks (SIFA) has led to a renewed interest in fault attacks. SIFA requires minimal knowledge of the concrete implementation and is effective even in the presence of common fault or power analysis countermeasures. However, further investigations reveal that undesired and frequent ineffective events, which we refer to as the noise phenomenon, are the bottleneck of SIFA that can considerably diminish its strength. This includes noise associated with the attack’s setup and caused by the countermeasures utilized in the implementation. This research aims to address this significant drawback. We present two novel statistical fault attack variants that are far more successful in dealing with these noisy conditions. The first variant is the Statistical Effective Fault Attack (SEFA), which exploits the non-uniform distribution of intermediate variables in circumstances when the induced faults are effective. The idea behind the second proposed method, dubbed Statistical Hybrid Fault Attacks (SHFA), is to take advantage of the biased distributions of both effective and ineffective cases simultaneously. Our experimental results in various case studies, including noise-free and noisy setups, back up our reasoning that SEFA surpasses SIFA in several instances and that SHFA outperforms both or is at least as efficient as the best of them

Therapeutic Effects of Photobiomodulation Therapy on Multiple Sclerosis by Regulating the Inflammatory Process and Controlling Immune Cell Activity: A Novel Promising Treatment Target

Introduction: Multiple sclerosis (MS) is one of the autoimmune and chronic diseases of the central ‎nervous system, this disease occurs more frequently in young people and women ‎and leads to neurological symptoms. Oxidative stress, inflammatory process, and ‎oligodendrocyte dysfunction has a pivotal role in the pathophysiology of this ‎disease. Nowadays, it has been reported that Photobiomodulation (PBM) as a non-invasive threat has neuroprotective potential but the exact mechanisms are not understood.   Methods: In this manuscript, we have reviewed the Photobiomodulation effects on MS. in this regard, we used "Photobiomodulation", " Laser therapy", and "Low-level laser therapy" keywords on MS to find related studies on this subject in PubMed, Google scholar, Elsevier, Medline, and Scopus databases.  Results: Photobiomodulation has positive effects on MS by regulating the inflammatory ‎process, controlling immune cell activity, and mitochondrial functions, as well as inhibiting free ‎radicals’ production. ‎ Conclusion: Overall, researchers have suggested that laser therapy could be considered a promising new treatment for neurodegenerative diseases, such as multiple sclerosis

Therapeutic Effects of Combination Therapy and Photobiomodulation Therapy on Retinal Regeneration

Introduction: Macular edema (ME) is produced by central extravascular inflammation of the macula subsequent to a major loss of visual action. Macular edema can happen at any phase of diabetic retinopathy, whether non-proliferative or proliferative retinopathy. Method and material: Articles were collected from four electronic databases PubMed, Google Scholar Web of Science from 2000 to 2022 and electronically to study the effects of macular laser grid photocoagulation on Diabetic macular edema or Cystoid macular edema through the keywords " macular laser photocoagulation ", " macular edema ", " Cystoid macular edema ", " Intravitreal pharmacotherapies ", " Antivascular endothelial growth factor “, were searched about 219 articles found in google scholar and 165 articles in PubMed, that   58 articles were included in the study. Result: In this study, the effects of various laser photocoagulation such as Focal and/or grid macular laser, subthreshold micropulse laser (SMPL), and Intravitreal pharmacotherapies (Corticosteroids such as triamcinolone acetonide, fluocinolone, Bevacizumab, and dexamethasone) on macular edema were investigated. A few studies had shown that the effects of corticosteroids are more effective than lasers, and a number of studies have found the effects of lasers and the combined effects of lasers with corticosteroids to be more effective. Also, some studies have also shown that the frequency and duration of follow-up and concentrations of intravitreal pharmacotherapies are effective in increasing visual outcomes. Conclusion: The results of studies showed that although corticosteroids have side effects, the combined effects of corticosteroids with subthreshold micropulse laser are effective in increasing visual acuity (VA) and central macular thickness (CMT)

Protective effect of Photobiomodulation Therapy and Bone Marrow Stromal Stem Cells Conditioned Media on Pheochromocytoma Cell Line 12 Against Oxidative Stress Induced by Hydrogen Peroxide

Introduction: Bone marrow stromal stem cells (BMSCs), a type of adult stem cells, secrete bioactive molecules such as trophic factors, growth factors, chemokine and cytokines that may be effective against oxidative stress in neurodegenerative diseases.In this study, we examined the protective effect of BMSCs conditioned media CM) and photobiomodulation therapy (PBMT) on PC12 cells exposed to H2O2 as an oxidative injury model.Methods: BMSCs were cultured and confirmed by flow cytometry analysis and underwent osteogenic and adipogenic differentiation. Then, PC12-H2O2 cells were co-treated with BMSCs-CM and PBMT. The effect of BMSCs-CM and PBMT (He-Ne laser, 632.8 nm, 3 mW, 1.2 J/cm2, 378 s) on Bax/Bcl2 expression, cell viability, was assessed by real-time PCR and MTT assay. The length of the Neurite and cell body areas were assessed by Cell A software.Results: Flowcytometry analysis, as well as osteogenic and adipogenic staining, confirmed the BMSCs. The length of the Neurite was the highest in the group which received CM+PBMT and cell body areas were significant in CM+PBMT compared to other groups. Based on our results, elevating H2O2 concentration increased cell death significantly and using concentrations of 250 μM resulted in a dramatic increase in the mortality compared to the other groups.Conclusion: Our result demonstrated that the combination of CM +PBMT has a protective effect on PC12 cells against oxidative stress

Electron Weibel instability induced magnetic fields in optical-field ionized plasmas

Generation and amplification of magnetic fields in plasmas is a long-standing topic that is of great interest to both plasma and space physics. The electron Weibel instability is a well-known mechanism responsible for self-generating magnetic fields in plasmas with temperature anisotropy and has been extensively investigated in both theory and simulations, yet experimental verification of this instability has been challenging. Recently, we demonstrated a new experimental platform that enables the controlled initialization of highly nonthermal and/or anisotropic plasma electron velocity distributions via optical-field ionization. Using an external electron probe bunch from a linear accelerator, the onset, saturation and decay of the self-generated magnetic fields due to electron Weibel instability were measured for the first time to our knowledge. In this paper, we will first present experimental results on time-resolved measurements of the Weibel magnetic fields in non-relativistic plasmas produced by Ti:Sapphire laser pulses (0.8 $\mu m$) and then discuss the feasibility of extending the study to quasi-relativistic regime by using intense $\rm CO_2$ (e.g., 9.2 $\mu m$) lasers to produce much hotter plasmas.Comment: 22 pages, 10 figure

Mapping the self-generated magnetic fields due to thermal Weibel instability

Weibel-type instability can self-generate and amplify magnetic fields in both space and laboratory plasmas with temperature anisotropy. The electron Weibel instability has generally proven more challenging to measure than its ion counterpart owing to the much smaller inertia of electrons, resulting in a faster growth rate and smaller characteristic wavelength. Here, we have probed the evolution of the two-dimensional distribution of the magnetic field components and the current density due to electron Weibel instability, in $\rm CO_2$-ionized hydrogen gas (plasma) with picosecond resolution using a relativistic electron beam. We find that the wavenumber spectra of the magnetic fields are initially broad but eventually shrink to a narrow spectrum representing the dominant quasi-single mode. The measured $k$-resolved growth rates of the instability validate kinetic theory. Concurrently, self-organization of microscopic plasma currents is observed to amplify the current modulation magnitude that converts up to $\sim 1\%$ of the plasma thermal energy into magnetic energy.Comment: 24 pages, 4 figure

Demonstration of a positron beam-driven hollow channel plasma wakefield accelerator

International audiencePlasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that may disrupt the beam quality. Hollow plasma channels have been proposed as a technique for generating accelerating fields without transverse forces. Here we demonstrate a method for creating an extended hollow plasma channel and measure the wakefields created by an ultrarelativistic positron beam as it propagates through the channel. The plasma channel is created by directing a high-intensity laser pulse with a spatially modulated profile into lithium vapour, which results in an annular region of ionization. A peak decelerating field of 230 MeV/m is inferred from changes in the beam energy spectrum, in good agreement with theory and particle-in-cell simulations

Experimental Investigations of Beam Driven Plasma Wakefield Accelerators

A plasma wakefield accelerator (PWFA) uses a plasma wave (a wake) to accelerate electrons at a gradient that is three orders of magnitude higher than that of a conventional accelerator. When the plasma wave is driven by a high-density particle beam or a high-intensity laser pulse, it evolves into the nonlinear blowout regime, where the driver expels the background plasma electrons, resulting in an ion cavity forming behind the driver. This ion cavity has ideal properties for accelerating and focusing electrons. One method to insert electrons into this highly-relativistic, transient structure is by ionization injection. In this method, electrons resulting from further ionization of the ions inside the wake are trapped and accelerated by the wakefield. These injected electrons absorb the energy of the wake, resulting in a reduced accelerating field amplitude; this phenomenon is known as beam loading.This thesis discusses experiments that demonstrate how ionization injection can, on the one hand, lead to excessive beam loading and be a detriment to a PWFA, while on the other hand, it may be taken advantage of to produce bright electron beams that will be necessary for applications of a PWFA to a free electron laser (FEL) or a collider. These experiments were part of the FACET Campaign at the SLAC National Accelerator Laboratory and used FACET’s 3 nC, 20.35 GeV electron beam to field ionize the plasma source and drive a wake.In the first experiment, the plasma source was a 30 cm column of rubidium (Rb) vapor. The low ionization potential and high atomic mass of Rb made it a suitable candidate as a plasma source for a PWFA. However, the low ionization potential of the Rb+ ion resulted in continuous ionization of Rb+ and injection of electrons along the length of the plasma. This resulted in heavy beam-loading, which reduced the strength of the accelerating field by half, making the Rb source unusable for a PWFA.In the second experiment, the plasma source was a column of lithium (Li) vapor bound by cold helium (He) gas. Here, the ionization injection of He electrons in the 10 cm boundary region between Li and He led to localized beam loading and resulted in an accelerated electron beam with high energy (32 GeV), a 10% energy spread, and an emittance an order of magnitude smaller than the drive beam. Particle-in-cell simulations indicate that the beam loading can be further optimized by reducing the injection region even more, which can lead to bright, high-current, low-energy-spread electron beams

High-Peak-Power Long-Wave Infrared Lasers with CO2 Amplifiers

Long-wave infrared (LWIR) picosecond pulses with multi-terawatt peak power have recently become available for advanced high-energy physics and material research. Multi-joule pulse energy is achieved in an LWIR laser system via amplification of a microjoule seed pulse with high-pressure, mixed-isotope CO2 amplifiers. A chirped-pulse amplification (CPA) scheme is employed in such a laser to reduce the nonlinear interaction between the optical field and the transmissive elements of the system. Presently, a research and development effort is underway towards an even higher LWIR peak power that is required, for instance, for promising particle acceleration schemes. The required boost of the peak power can be achieved by reducing the pulse duration to fractions of a picosecond. For this purpose, the possibility of reducing the gain narrowing in the laser amplifiers and post-compression techniques are being studied. Another direction in research is aimed at the increased throughput (i.e., repetition rate), efficiency, and reliability of LWIR laser systems. The transition from a traditional electric-discharge pumping to an optical pumping scheme for CO2 amplifiers is expected to improve the robustness of high-peak-power LWIR lasers, making them suitable for broad implementation in scientific laboratory, industrial, and clinical environments